Determining the pharmacokinetics and the pharmacodynamics of candidate drugs are important components in drug discovery. Likewise, understanding drug penetration into target tissue(s) and its distribution, along with any metabolites, are also major milestones in the successful drug development process as well.
As a researcher in the pharmaceutical industry who performs tissue analysis for drug and metabolite fate, your research benefits from spatially-resolved, unambiguous identification of drugs and their metabolites in intact animal tissue sections—without the requirement for synthetic radiolabelled molecules. With this improved process, you can yield faster results for significant improvement of efficiency during preclinical research.
The DESI 2D and flowprobe enable direct analysis of intact tissue using mass spectrometry by analyzing them in situ—without homogenization and extraction—to provide unambiguous detection of drugs and metabolites.